Application of Micro Diaphragm Pump in Water Circulation System of IVD Instrument

What is an IVD?
IVD is a kind of medical device, which refers to products and services that obtain clinical diagnosis information by detecting human samples (blood, body fluids, tissues, etc.) through relevant instruments outside the human body, and then judge diseases or body functions. At present, about 80% of the disease diagnosis depends on in vitro diagnosis, so it is called "doctor's eyes"
The "inspection" commonly known in Chinese hospitals includes most subdivided types of IVD - such as biochemical diagnosis, immune diagnosis, molecular diagnosis, element diagnosis, microbiological diagnosis, urine diagnosis, coagulation diagnosis, tissue diagnosis, diagnostics, hematology and flow cytometry, etc. Since in vitro diagnostic products do not directly act on the human body, they are classified as "non-contact human body devices" in the "Medical Device Classification Rules".

The Development Status of China's IVD Market
With the improvement of Chinese people's living standards, people pay more and more attention to their own health, which further promotes the vigorous development of the IVD industry. In the IVD market structure, the five multinational giants occupying more than 5% of the market share constitute the first echelon of the domestic IVD industry, accounting for a total of 36.8% of the domestic market share. Excellent domestic enterprises form the second echelon, accounting for about 20% of the market share.
In recent years, with breakthroughs in domestic key technologies and key components, the market share and technical capabilities of domestic IVD companies have increased rapidly. According to the research data of the China Business Research Institute, the domestic in vitro diagnostic market will reach 124.3 billion in 2021, a year-on-year increase of 19%, and maintain a growth rate of about 20% in the rest of the year, which is higher than the global market.

Micro diaphragm pumps are the power components of IVD instrument
In IVD instrument, the micro liquid pump is an important power part of in vitro diagnostic analysis and a power component of the hydraulic system. It is widely used in clinical chemistry, blood analysis, immunology, microbiology and many other fields to complete important functions such as sample delivery, waste liquid removal, pipeline and component cleaning.

1. Schematic diagram of IVD in vitro diagnosis:

 
2. The main link of the liquid circuit treatment:
Sample dosing--Dispensing reagents---Pipeline cleaning---Waste liquid removal

(1) Sample dosing and reagent distribution: These two links are to add samples and reagents to the analysis room with high precision. The flow and pressure parameters are not high, but the sampling system has the characteristics of high precision, long life, no pollution, and high reliability. Therefore, the requirements for the flow accuracy of the pump are very high.



(2) Pipeline cleaning: In this stage, the pipeline and needle need to be sterilized with a disinfectant, and then the residue is rinsed with dc water pump. Corrosive solvents are often used to flush the pipeline and needle, and the waste liquid containing crystals or blood clots needs to be discharged from the system in time. In order to ensure the cleaning effect, the dc water pump is required to have a certain degree of corrosion resistance and to be able to continuously output high-pressure and high-flow water.

(3) Waste liquid cleaning: This link is to clean and remove the waste liquid in the cuvette and pipeline. In this link, the diaphragm liquid pump is used to directly pump out the waste liquid, and this scheme can be simplified into a gas pipeline. It is also possible to use a micro vacuum pump to evacuate the airtight container to indirectly suck out the waste liquid in the instrument, which has high efficiency, and the waste liquid does not pass through the pump chamber, which improves the service life of the pump.

Based on the demand for micro pumps related to the development of IVD analysis market technology, in order to help domestic IVD companies realize the localization of key components, TOPSFLO has integrated a full range of products and launched a micro diaphragm pump application solution for the IVD industry. In addition to meeting the above characteristic requirements, it can also be customized according to user needs to help more demands for IVD equipment.